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Fusicoccin

Cat. No. M22396
Fusicoccin Structure
Synonym:

NSC 113500

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Biological Activity

Fusicoccin

Chemical Information
Molecular Weight 680.82
Formula C36H56O12
CAS Number 20108-30-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hendrik J Brink, et al. ACS Chem Biol. Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3

[2] Mauro Marra, et al. Biomolecules. The Surprising Story of Fusicoccin: A Wilt-Inducing Phytotoxin, a Tool in Plant Physiology and a 14-3-3-Targeted Drug

[3] Małgorzata Polak, et al. Int J Mol Sci. Fusicoccin (FC)-Induced Rapid Growth, Proton Extrusion and Membrane Potential Changes in Maize ( Zea mays L.) Coleoptile Cells: Comparison to Auxin Responses

[4] Claire S Harmange Magnani, et al. Cell Chem Biol. Fusicoccin Keeps Getting Stickier: Modulation of an Adaptor Protein Interactome with a Molecular Glue Leads to Neurite Outgrowth

[5] Lorenzo Camoni, et al. Planta. From plant physiology to pharmacology: fusicoccin leaves the leaves

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