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Furprofen

Cat. No. M14043
Furprofen Structure
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Biological Activity

Furprofen is an non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain.

Chemical Information
Molecular Weight 244.24
CAS Number 66318-17-0
Solubility (25°C) Ethanol 90 mg/mL
DMSO 62.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A Tartaglia, et al. Fast off-line FPSE-HPLC-PDA determination of six NSAIDs in saliva samples

[2] Vincenzo Ferrone, et al. Dispersive magnetic solid phase extraction exploiting magnetic graphene nanocomposite coupled with UHPLC-PDA for simultaneous determination of NSAIDs in human plasma and urine

[3] Marcello Locatelli, et al. Microextraction by packed sorbent and high performance liquid chromatography determination of seven non-steroidal anti-inflammatory drugs in human plasma and urine

[4] G Carlucci, et al. A high performance liquid chromatographic procedure for the simultaneous determination of norfloxacin and furprofen in rat plasma

[5] G Carlucci, et al. Quantitation of the enantiomers of furprofen in biological fluids by high-performance liquid chromatography

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