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FR901379

Cat. No. M25433
FR901379 Structure
Synonym:

FR-901-379

Size Price Availability Quantity
10mg USD 600  USD600 In stock
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Quality Control & Documentation
Biological Activity

FR901379 is an antifungal lipopeptide.

Chemical Information
Molecular Weight 1175.31
Formula C51H82N8O21S
CAS Number 144371-88-0
Solubility (25°C) DMSO
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ping Men, et al. Microb Cell Fact. Improving the production of the micafungin precursor FR901379 in an industrial production strain

[2] Teng-Yun Wei, et al. ACS Chem Biol. Analysis of FR901379 Biosynthetic Genes in Coleophoma empetri by Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Based Genomic Manipulation

[3] Satoshi Ueda, et al. J Biosci Bioeng. Strain selection and scale-up fermentation for FR901379 acylase production by Streptomyces sp. no. 6907

[4] Satoshi Ueda, et al. J Antibiot (Tokyo). Screening and characterization of microorganisms with FR901379 acylase activity

[5] Munekazu Kanda, et al. J Biosci Bioeng. Improvement of FR901379 production by mutant selection and medium optimization

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Keywords: FR901379, FR-901-379 supplier, Anti-infection, inhibitors, activators


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