Free shipping on all orders over $ 500

FR181157

Cat. No. M41907

All AbMole products are for research use only, cannot be used for human consumption.

FR181157 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

FR181157, an orally active PGI2 agonist activity with especially good pharmacokinetic properties.

Chemical Information
Molecular Weight 487.52
Formula C30H26NNaO4
CAS Number 171046-15-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Akira Tanaka et al. Bioorg Med Chem Lett. Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6

[2] Kouji Hattori et al. Bioorg Med Chem Lett. Metabolism investigation leading to novel drug design: orally active prostacyclin mimetics. Part 4

[3] Kouji Hattori et al. Bioorg Med Chem Lett. A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic

Related Prostaglandin Receptor Products
Prostaglandin D2

Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. PGD2 plays a protective role by suppressing inflammation.

Tafluprost acid

Tafluprost acid (AFP-172) is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor.

TG8-260 

TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation.

Camonagrel 

Camonagrel is a compound that has inhibitory effects on Prostaglandin E2.

BAY 73-1449 

BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG.

  Catalog
Abmole Inhibitor Catalog




Keywords: FR181157 supplier, Prostaglandin Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.