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Fosravuconazole L-lysine ethanolate

Cat. No. M30883
Fosravuconazole L-lysine ethanolate Structure
Synonym:

BMS-379224 L-lysine ethanolate; E-1224 L-lysine ethanolate

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Biological Activity

Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a proagent of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used for candidiasis, onychomycosis and parasitemia research.

Chemical Information
Molecular Weight 739.73
Formula C31H40F2N7O8PS
CAS Number 914361-45-8
Form Solid
Solubility (25°C) Water 50 mg/mL (ultrasonic)
DMSO 50 mg/mL (ultrasonic)
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tomohiro Suzuki, et al. Med Mycol J. A Case of Tinea Faciei, Tinea Corporis, and Tinea Unguium with Dermatophytoma Successfully Treated with Oral Fosravuconazole L-lysine Ethanolate

[2] Yuka Kumano, et al. Eur J Dermatol. Erythro-papular type drug eruption caused by fosravuconazole L-lysine ethanolate

[3] Ryosuke Takeshima, et al. J Dermatol. Tinea barbae due to Trichophyton rubrum successfully treated using oral fosravuconazole l-lysine ethanolate

[4] Makoto Nakano, et al. Nihon Yakurigaku Zasshi. [Drug properties of fosravuconazole L-lysine ethanolate (NAILIN® Capsules 100 mg), a new oral azole therapeutic for onychomycosis: an analysis based on non-clinical and clinical trial data]

[5] Shinichi Watanabe, et al. J Dermatol. Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study

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Keywords: Fosravuconazole L-lysine ethanolate, BMS-379224 L-lysine ethanolate; E-1224 L-lysine ethanolate supplier, Antifungal, inhibitors, activators

 
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