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fluticasone furoate

Cat. No. M20963
fluticasone furoate Structure


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Biological Activity

Fluticasone furoate is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.

Chemical Information
Molecular Weight 538.58
Formula C27H29F3O6S
CAS Number 397864-44-7
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Afisi S Ismaila, et al. Adv Ther. Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Triple Therapy Compared with Other Therapies for the Treatment of COPD: A Network Meta-Analysis

[2] Simon Couillard, et al. Respirology. Fluticasone furoate: CAPTAIN of fluticasones in type 2 inflammatory asthma

[3] Yamei Zhang, et al. Pediatr Res. Intranasal fluticasone furoate in pediatric allergic rhinitis: randomized controlled study

[4] David A Lipson, et al. Am J Respir Crit Care Med. Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease

[5] No authors listed. Fluticasone Furoate/Vilanterol (Breo Ellipta) [Internet]

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