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FLT3 Inhibitor III

Cat. No. M22399
FLT3 Inhibitor III Structure
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Biological Activity

FLT3 Inhibitor III

Chemical Information
Molecular Weight 365.5
Formula C21H23N3OS
CAS Number 852045-46-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Naval Daver, et al. J Clin Oncol. Venetoclax Plus Gilteritinib for FLT3-Mutated Relapsed/Refractory Acute Myeloid Leukemia

[2] Hartmut Dhner, et al. Blood. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

[3] Hartmut Dhner, et al. Nat Rev Clin Oncol. Towards precision medicine for AML

[4] Hitoshi Kiyoi, et al. Cancer Sci. FLT3 mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development

[5] Alexander E Perl, et al. N Engl J Med. Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML

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