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FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM. FLLL32 is a small molecule analog of curcumin. It can inhibit signal transducer and activator of transcription-3 (STAT3). In the pSTAT3-positive A375 cell line, FLLL32 resulted in pro-apoptotic effects with an IC50 value of 1.3 μM at 48 hours.
In an s.c. model of B16F10 melanoma in C57BL/6 mice, compared to the treatment with DMSO to the same animals, daily i.p. administration of FLLL-32 at concentrations of 25 mg/kg and 50 mg/kg significantly delayed tumor growth (p<0.001).
Biochem Biophys Res Commun. 2024 Oct 28;737:150919.
Flll32, a curcumin analog, improves adipose tissue thermogenesis
FLLL32 purchased from AbMole
| Molecular Weight | 464.55 |
| Formula | C28H32O6 |
| CAS Number | 1226895-15-3 |
| Solubility (25°C) | DMSO: ≥ 60 mg/mL |
| Storage | 2-8°C, protect from light |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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