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Finerenone (BAY 94-8862) is a third generation selective, oral active, non-steroidal halocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone showed good selectivity (>500-fold) compared to glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (AR). Finerenone has potential applications in the study of heart and kidney diseases, such as type 2 diabetes and chronic kidney disease.
| Cell Experiment | |
|---|---|
| Cell lines | Human coronary artery smooth muscle cells |
| Preparation method | Cells are incubated with aldosterone with or without finerenone for 24 hours after 24 hours of serum-starvation for the assessment of cell proliferation and apoptosis. Immediately prior to the addition of aldosterone, cells are preincubated with finerenone or vehicle for 30 minutes. |
| Concentrations | 1 nM, 10 nM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Twelve-week-old MWF, aged-matched normoalbuminuric Wistar rats |
| Formulation | in 10% EtOH, 40% PEG400, 50% water |
| Dosages | 10 mg/kg/day |
| Administration | p.o. |
| Molecular Weight | 378.43 |
| Formula | C21H22N4O3 |
| CAS Number | 1050477-31-0 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Mineralocorticoid Receptor Products |
|---|
| 18-Oxocortisol
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). |
| Lorundrostat
Lorundrostat is an aldosterone synthase inhibitor and is used in studies related to hypertension. |
| LY2623091
LY2623091 is a salicorticoid receptor (MR) antagonist that may be used in studies related to chronic kidney disease and hypertension. |
| Desoxycorticosterone pivalate
Desoxycorticosterone pivalate (DOCP) is a salt corticosteroid that may be used in studies related to primary hypoadrenocorticism (PH). |
| Ocedurenone
Ocedurenone is a novel nonsteroidal salicorticoid receptor (MR) antagonist that may be used in studies related to kidney disease. |
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