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Filibuvir 

Cat. No. M30786

All AbMole products are for research use only, cannot be used for human consumption.

Filibuvir  Structure

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Quality Control & Documentation
Biological Activity

Filibuvir is an orally active, selective non-nucleoside inhibitor of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase (RdRp). Filibuvir binds noncovalently in the thumb II allosteric pocket of NS5B. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM for both isoforms, respectively. Filibuvir preferentially inhibits elongative RNA synthesis and potently decreases viral RNA accumulation.

Chemical Information
Molecular Weight 503.64
Formula C29H37N5O3
CAS Number 877130-28-4
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Huiqun Wang, et al. Antiviral Res. Computational study on the drug resistance mechanism of HCV NS5B RNA-dependent RNA polymerase mutants V494I, V494A, M426A, and M423T to Filibuvir

[2] Maribel Rodriguez-Torres, et al. Ann Hepatol. A phase 2 study of filibuvir in combination with pegylated IFN alfa and ribavirin for chronic HCV

[3] Philip J F Troke, et al. Antimicrob Agents Chemother. Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients

[4] Frank Wagner, et al. Hepatology. Antiviral activity of the hepatitis C virus polymerase inhibitor filibuvir in genotype 1-infected patients

[5] Pierre L Beaulieu. IDrugs. Filibuvir, a non-nucleoside NS5B polymerase inhibitor for the potential oral treatment of chronic HCV infection

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Abmole Inhibitor Catalog




Keywords: Filibuvir  supplier, Anti-infection, inhibitors, activators

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