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FGF-basic, Rat(E. coli)

Cat. No. M11496
FGF-basic, Rat(E. coli) Structure
Synonym:

Fibroblast Growth Factor-basic; FGF-2; BFGF; FGFB; HBGF-2; bFGF; Prostatropin

Size Price Availability Quantity
10ug USD 130  USD130 In stock
50ug USD 230  USD230 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Expression system: E. coli
Purity: SDS-PAGE > 95%
Endotoxin: protein < 0.2 EU/μg was determined by gel coagulation
Apparent molecular weight: ~16.4 kDa, reduced by SDS-PAGE.
Storage and stability: After receiving, the product remains stable at temperatures below -70°C for up to 6 months. After recombination, the product should be stable at 4°C for 1 week or -20°C for 3 months. For long-term preservation, carrier protein (e.g. 0.1% BSA) is recommended. Avoid repeated freeze-thaw cycles.

Biological Activity: Basic fibroblast growth factor (FGF-BASIC)(E. coli), also known as FGF-2, is a multipotent cytokine and one of the prototype members of the heparin-binding FGF family. Like other MEMBERS of the FGF family, alkaline FGF has a β trilobular structure. In vivo, BASIC fibroblast factor is produced by a variety of cells, including myocardial microbiota, fibroblasts, and vascular cells. BFGF regulates a variety of processes, including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation, and wound healing.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 0.2 EU/μg
Solubility Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml.
Storage at -20°C
References

[1] Yong Li, et al. J Cardiovasc Pharmacol. Effect of NRG-1/ErbB signaling intervention on the differentiation of bone marrow stromal cells into sinus node-like cells

[2] F Marn, et al. J Pineal Res. Immunocytochemical localization of basic fibroblast growth factor in the rat pineal gland

[3] A U Dignass, et al. Gastroenterology. Fibroblast growth factors modulate intestinal epithelial cell growth and migration

[4] H Iwata, et al. Brain Res. Localization of basic FGF-like immunoreactivity in the hypothalamo-hypophyseal neuroendocrine axis

[5] J W Moore, et al. Development. The mRNAs encoding acidic FGF, basic FGF and FGF receptor are coordinately downregulated during myogenic differentiation

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Keywords: FGF-basic, Rat(E. coli), Fibroblast Growth Factor-basic; FGF-2; BFGF; FGFB; HBGF-2; bFGF; Prostatropin supplier, Cytokines, inhibitors

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