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Ferulic Acid

Cat. No. M3897
Ferulic Acid Structure
Synonym:

Coniferic acid

Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 100  USD100 In stock
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Quality Control
Biological Activity

Ferulic acid is a chemopreventive caffeic acid analogue. Ferulic acid is an inhibitor of 5-LO (5-lipoxygenase) and 12-LO (12-lipoxygenase).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 194.18
Formula C10H10O4
CAS Number 1135-24-6
Purity 99.86%
Solubility DMSO 30 mg/mL
Storage 2-8°C, sealed
References

[1] Dan Li, et al. Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives

[2] Gabriela R Cavalcanti, et al. Ferulic Acid Activity in Topical Formulations: Technological and Scientific Prospecting

[3] Ashun Chaudhary, et al. Ferulic Acid: A Promising Therapeutic Phytochemical and Recent Patents Advances

[4] Mao Mu, et al. Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

[5] Kamila Zduńska, et al. Antioxidant Properties of Ferulic Acid and Its Possible Application

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Keywords: Ferulic Acid, Coniferic acid supplier, FGFR, inhibitors

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