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EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas.
| Molecular Weight | 498.94 |
| Formula | C23H19ClN4O5S |
| CAS Number | 1016456-76-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 83.33 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Tridib Mondal, et al. Biochemistry. ApoE: In Vitro Studies of a Small Molecule Effector
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