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EZ-482 

Cat. No. M27641

All AbMole products are for research use only, cannot be used for human consumption.

EZ-482  Structure

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Quality Control & Documentation
Biological Activity

EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas.

Chemical Information
Molecular Weight 498.94
Formula C23H19ClN4O5S
CAS Number 1016456-76-0
Form Solid
Solubility (25°C) DMSO 83.33 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Naisheng Zheng, et al. Oncoimmunology. M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance

[2] Tridib Mondal, et al. Biochemistry. ApoE: In Vitro Studies of a Small Molecule Effector

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  Catalog
Abmole Inhibitor Catalog




Keywords: EZ-482  supplier, inhibitors, activators

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