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Etofenamate

Cat. No. M20675
Etofenamate Structure
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Quality Control & Documentation
Biological Activity

Etofenamate is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.

Chemical Information
Molecular Weight 369.34
Formula C18H18F3NO4
CAS Number 30544-47-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hans-Georg Predel, et al. Orthop J Sports Med. Efficacy and Safety of an Etofenamate Medicated Plaster for Acute Ankle Sprain: A Randomized Controlled Trial

[2] Giuliana Mancini, et al. Pharmaceutics. Increased Therapeutic Efficacy of SLN Containing Etofenamate and Ibuprofen in Topical Treatment of Inflammation

[3] Olga Daniela Silva Marinho, et al. Pain Ther. Clinical Efficacy and Safety Profile of Topical Etofenamate in the Treatment of Patients with Musculoskeletal Disorders: A Systematic Review

[4] Savaş Gner, et al. Ther Clin Risk Manag. Effectiveness of etofenamate for treatment of knee osteoarthritis: a randomized controlled trial

[5] T Bender, et al. Arzneimittelforschung. Etofenamate levels in human serum and synovial fluid following iontophoresis

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