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Ethyl p-methoxycinnamate

Cat. No. M18271
Ethyl p-methoxycinnamate Structure
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Biological Activity

Ethyl p-methoxycinnamate

Chemical Information
Molecular Weight 206.24
Formula C12H14O3
CAS Number 24393-56-4
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lusi Putri Dwita, et al. J Tradit Complement Med. Extract, fractions, and ethyl- p-methoxycinnamate isolate from Kaempferia galanga Elicit anti-inflammatory activity by limiting leukotriene B4 (LTB4) production

[2] Nupur Srivastava, et al. J Ethnopharmacol. Standardization of Kaempferia galanga L. rhizome and vasorelaxation effect of its key metabolite ethyl p-methoxycinnamate

[3] Huihan Ai, et al. Biochem Pharmacol. Ethyl-p-methoxycinnamate enhances oct4 expression and reinforces pluripotency through the NF-κB signaling pathway

[4] Muhammad Ihtisham Umar, et al. Clinics (Sao Paulo). Ethyl-p-methoxycinnamate isolated from Kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-α, and angiogenesis by blocking endothelial functions

[5] Hyun-Ju Ko, et al. Phytother Res. Hypopigmentary effects of ethyl P-methoxycinnamate isolated from Kaempferia galanga

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