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Ethoxylated hydrogenated castor oil

Cat. No. M21563
Ethoxylated hydrogenated castor oil Structure
Synonym:

PEG-40 hydrogenated castor oil; Macrogolglycerol hydroxystearate; Castor oil, hydrogenated, polyethoxylated

Size Price Availability Quantity
1g USD 48  USD48 In stock
5g USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Ethoxylated castor oil (PEG-40 hydrogenated castor oil) is a mixture of polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used for emulsification and solubility of oil-in-water (o/w) emulsions. Ethoxylated hydrogenated castor oil can be used as a co-solvent for animal experiments.

Chemical Information
CAS Number 61788-85-0
Solubility (25°C) Water ≥ 60 mg/mL
Storage 2-8℃, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jingjing Yang, et al. Pharmaceutics. Development of a Luliconazole Nanoemulsion as a Prospective Ophthalmic Delivery System for the Treatment of Fungal Keratitis: In Vitro and In Vivo Evaluation

[2] Joo A Oshiro-Junior, et al. Mater Sci Eng C Mater Biol Appl. Phthalocyanine-loaded nanostructured lipid carriers functionalized with folic acid for photodynamic therapy

[3] Mika Yoshimura Fujii, et al. Int J Pharm. Potential application of novel liquid crystal nanoparticles of isostearyl glyceryl ether for transdermal delivery of 4-biphenyl acetic acid

[4] Thierry Fouquet, et al. J Oleo Sci. High-resolution Kendrick Mass Defect Analysis of Poly(ethylene oxide)-based Non-ionic Surfactants and Their Degradation Products

[5] Hua Ming Zheng, et al. J Food Sci. Preparation methods for monodispersed garlic oil microspheres in water using the microemulsion technique and their potential as antimicrobials

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Keywords: Ethoxylated hydrogenated castor oil, PEG-40 hydrogenated castor oil; Macrogolglycerol hydroxystearate; Castor oil, hydrogenated, polyethoxylated supplier, inhibitors, activators


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