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Ethopabate

Cat. No. M19878
Ethopabate Structure
Synonym:

Ethyl pabate

Size Price Availability Quantity
100mg USD 55  USD55 In stock
500mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Ethopabate (ETP) is a coccidiostat that is frequently used to prevent and treat coccidiosis in chickens.

Chemical Information
Molecular Weight 237.25
Formula C12H15NO4
CAS Number 59-06-3
Solubility (25°C) DMSO 47 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mohamed H Aboumanei, et al. Appl Radiat Isot. Evaluation of radioiodinated ethopabate as a potential tumor targeting agent

[2] Sona Barghash, et al. Luminescence. Novel spectrofluorimetric technique for determination of amoxicillin and ethopabate in chicken tissues, liver, kidney, eggs, and feed premix

[3] Mai A Basha, et al. Spectrochim Acta A Mol Biomol Spectrosc. A comparative study of two analytical techniques for the simultaneous determination of amprolium HCl and ethopabate from combined dosage form and in presence of their alkaline degradation

[4] Mostafa M Baker, et al. J Sep Sci. Comprehensive stability-indicating high-performance liquid chromatography coupled with diode array detection method for simultaneous determination of amprolium hydrochloride and ethopabate in powder dosage form for veterinary use

[5] Jenny Jeehan Nasr, et al. Luminescence. Spectrofluorimetric analysis of ethopabate in veterinary formulations with application to residue determination in chicken muscles and liver

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