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Estradiol Cypionate

Cat. No. M2684
Estradiol Cypionate Structure
Synonym:

Depoestradiol

Size Price Availability Quantity
100mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

Chemical Information
Molecular Weight 396.56
Formula C26H36O3
CAS Number 313-06-4
Solubility (25°C) DMSO 60 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A Menchaca, et al. Estradiol cypionate treatment in suckling/weaning and estrous cycling/anestrous beef cows subjected to fixed-time artificial insemination

[2] D Bosolasco, et al. Estradiol cypionate administered at the end of a progesterone-based protocol for FTAI induces ovulation and improves postovulatory luteal function and uterine environment in anestrous beef cows

[3] Nelcio Antonio Tonizza de Carvalho, et al. Treatment with estradiol cypionate at progesterone withdrawal reduces handling without compromising the pregnancy rate to timed-AI in buffalo

[4] Roberto Salvador Martins, et al. Quantification of estradiol cypionate in plasma by liquid chromatography coupled with tandem mass spectrometry: Application in a pharmacokinetic study in healthy female volunteers

[5] No authors listed. Estradiol Cypionate

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Keywords: Estradiol Cypionate, Depoestradiol supplier, inhibitors, activators

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