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ESI 09 is a ePAC inhibitor with IC50 values of 3.2 and 1.4 μM for EPAC1 and EPAC2, respectively. ESI-09 inhibits EPAC-mediated insulin releases from pancreatic β cells. Selective for EPAC over PKA. ESI-09 decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.
| Molecular Weight | 330.77 |
| Formula | C16H15ClN4O2 |
| CAS Number | 263707-16-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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