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Esculetin

Cat. No. M14849
Esculetin Structure
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Biological Activity

Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities.

Chemical Information
Molecular Weight 178.14
CAS Number 305-01-1
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Linlin Zhang, et al. Esculetin: A review of its pharmacology and pharmacokinetics

[2] Seyed-Mahdi Mohamadi-Zarch, et al. Esculetin Alleviates Acute Liver Failure following Lipopolysaccharide/D-Galactosamine in Male C57BL/6 Mice

[3] Nermin Abdel Hamid Sadik, et al. Esculetin and idebenone ameliorate galactose-induced cataract in a rat model

[4] Chengyuan Liang, et al. Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review

[5] Almesh Kadakol, et al. Esculetin: A phytochemical endeavor fortifying effect against non-communicable diseases

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