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Esculentoside C

Cat. No. M42829
Esculentoside C Structure
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Biological Activity

Esculentoside C is a triterpene saponin.

Chemical Information
Molecular Weight 810.96
Formula C42H66O15
CAS Number 65931-92-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tao Liu et al. Clin Exp Pharmacol Physiol. Esculentoside A ameliorates DNCB-induced atopic dermatitis by suppressing the ROS-NLRP3 axis via activating the Nrf2 pathway

[2] Shuyi Gu et al. Phytother Res. Nephrotoxicity assessment of Esculentoside A using human-induced pluripotent stem cell-derived organoids

[3] Sanggil Choe et al. J Chromatogr B Analyt Technol Biomed Life Sci. Identification of phytolaccosides in biological samples from pokeweed intoxication patients using liquid chromatography-tandem mass spectrometry

[4] Qing Shao et al. Int Immunopharmacol. Esculentoside A protects against osteoarthritis by ameliorating inflammation and repressing osteoclastogenesis

[5] De-Zhun Chen et al. Microb Pathog. Esculentoside A inhibits LPS-induced acute kidney injury by activating PPAR-γ

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