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Ervogastat

Cat. No. M21575

All AbMole products are for research use only, cannot be used for human consumption.

Ervogastat Structure
Synonym:

PF-06865571

Size Price Availability Quantity
1mg USD 135  USD135 In stock
5mg USD 320  USD320 In stock
10mg USD 530  USD530 In stock
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Biological Activity

Ervogastat is a DGAT2 inhibitor that can be used in studies related to non-alcoholic steatohepatitis (NASH).

Chemical Information
Molecular Weight 407.42
Formula C21H21N5O4
CAS Number 2186700-33-2
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Raman Sharma, et al. Chem Res Toxicol. Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat

[2] Neeta B Amin, et al. Clin Ther. Inhibition of Diacylglycerol Acyltransferase 2 Versus Diacylglycerol Acyltransferase 1: Potential Therapeutic Implications of Pharmacology

[3] Kentaro Futatsugi, et al. J Med Chem. Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis

[4] Natasha R Catlin, et al. Toxicol Sci. The Postnatal Resolution of Developmental Toxicity Induced by Pharmacological Diacylglycerol Acyltransferase 2 (DGAT2) Inhibition During Gestation in Rats

[5] Neeta B Amin, et al. BMJ Open. Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, placebo-controlled MIRNA (Metabolic Interventions to Resolve NASH with fibrosis) study

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Keywords: Ervogastat, PF-06865571 supplier, DGAT, inhibitors, activators

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