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Erdosteine is an oral mucolytic agent used as an expectorant in various chronic respiratory diseases. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects. Erdosteine regulates mucus production and viscosity and increases mucociliary transport, thereby improving expectoration. Erdosteine also reveals inhibitory activity against the effects of free radicals produced by cigarette smoke. Erdosteine significantly inhibited citric acid-induced cough reflexes in guinea-pigs but did not suppress mechanical stimuli-induced cough reflexes.
| Molecular Weight | 249.31 |
| Formula | C8H11NO4S2 |
| CAS Number | 84611-23-4 |
| Solubility (25°C) | DMSO 40 mg/mL Water 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Mario Cazzola, et al. Multifaceted Beneficial Effects of Erdosteine: More than a Mucolytic Agent
[3] Mario Cazzola, et al. Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis
[4] Roberto W Dal Negro. Erdosteine: antitussive and anti-inflammatory effects
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