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Equisetin is a tetramic acid analog derived from Fusarium equisti. Equisetin is mainly known for its antibiotic and cytotoxic activity and for its inhibitory effect on HIV-1 integrase. Inhibition of HIV integrase by Equisetin was reported with IC50 values of 5-20 μM. Moreover, it was shown that Equisetin specifically inhibits the substrate anion carriers of the inner membrane of mitochondria and acts nonspecifically on protein membranes and protein hydrophobic domains. In addition, it was demonstrated that Equisetin causes phytotoxicity by causing root Necrosis and was also identified in a mycotoxin cocktail associated with cattle feeding problems.
| Molecular Weight | 373.49 |
| Formula | C22H31NO4 |
| CAS Number | 57749-43-6 |
| Solubility (25°C) | DMSO: soluble 1 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Erica C Larson, et al. Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase
[3] Mengmeng Zhang, et al. Equisetin as potential quorum sensing inhibitor of Pseudomonas aeruginosa
[4] Xiaojun Li, et al. Chemo-enzymatic synthesis of equisetin
[5] Jun Yin, et al. Biomimetic synthesis of equisetin and (+)-fusarisetin A
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