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Eplontersen is an N-acetylgalactosamine (GalNAc3)-suffixed antisense oligonucleotide (ASO) that targets the mRNA of the thyroxine transporter protein, TTR, and inhibits both variant and wild-type TTR production. It can be used in studies related to amyloidotic polyneuropathy.
| CAS Number | 1637600-16-8 |
| Solubility (25°C) | Water 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Tina Nie. Drugs. Correction: Eplontersen: First Approval
| Related Transthyretin (TTR) Products |
|---|
| WT-TTR inhibitor 1
WT-TTR inhibitor 1 is a wild-type Transthyretin (WT-TTR) inhibitor with 29.05% inhibition at 100 μM. |
| AS-Patisiran
Patisiran is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. |
| Vutrisiran
Vutrisiran is a liver-directed small interfering RNA (siRNA) that targets transthyretin protein (TTR) mRNA and can be used in TTR-mediated amyloidosis studies. |
| Patisiran
Patisiran is a small double-stranded interfering RNA that targets sequences within the Transthyretin (TTR) messenger RNA and specifically inhibits hepatic synthesis of mutant and wild-type TTR. It can be used to study hereditary TTR amyloidosis. |
| Inotersen
Inotersen is an antisense oligonucleotide that inhibits the production of the hepatic transthyretin (TTR) protein. It can be used in studies related to TTR-mediated amyloidosis. |
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