Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M10775 | Acoramidis | Acoramidis (AG10) is an orally active, selective stabilizer of the thyroxine transporter (TTR) that is effective against both wild-type and V1221 mutant types. |
| M10764 | Acoramidis hydrochloride | Acoramidis (AG10) hydrochloride is an orally active, selective stabilizer of the thyroxine transporter (TTR (transthyretin)) that is effective against both wild-type and V1221 mutant types. Acoramidis (AG10) hydrochloride can be used for the study of transthyroxine amyloidosis. |
| M6361 | A 1120 | A 1120 is a high-affinity antagonist of retinol-binding protein 4 (RBP4) with a Ki value of 8.3 nM that disrupts the interaction between RBP4 and its conjugate transthyretin. |
| M4847 | Tafamidis | Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade, with EC50s of 2.7-3.2 μM to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR. |
| M45133 | Eplontersen | Eplontersen is an N-acetylgalactosamine (GalNAc3)-suffixed antisense oligonucleotide (ASO) that targets the mRNA of the thyroxine transporter protein, TTR, and inhibits both variant and wild-type TTR production. It can be used in studies related to amyloidotic polyneuropathy. |
| M42715 | WT-TTR inhibitor 1 | WT-TTR inhibitor 1 is a wild-type Transthyretin (WT-TTR) inhibitor with 29.05% inhibition at 100 μM. |
| M42714 | AS-Patisiran | Patisiran is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. |
| M40955 | Vutrisiran | Vutrisiran is a liver-directed small interfering RNA (siRNA) that targets transthyretin protein (TTR) mRNA and can be used in TTR-mediated amyloidosis studies. |
| M40952 | Patisiran | Patisiran is a small double-stranded interfering RNA that targets sequences within the Transthyretin (TTR) messenger RNA and specifically inhibits hepatic synthesis of mutant and wild-type TTR. It can be used to study hereditary TTR amyloidosis. |
| M40947 | Inotersen | Inotersen is an antisense oligonucleotide that inhibits the production of the hepatic transthyretin (TTR) protein. It can be used in studies related to TTR-mediated amyloidosis. |
| M28920 | Dichlorophenyl-ABA | Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells. |
| M14778 | Tafamidis meglumine | Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. |
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