Epinastine hydrochloride is an antihistamine and mast cell stabilizer. Epinastine hydrochloride is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine hydrochloride also inhibits IL-8 release and has an antiallergic action
| Molecular Weight | 285.77 |
| Formula | C16H15N3.HCl |
| CAS Number | 108929-04-0 |
| Form | Solid |
| Solubility (25°C) | Water 80 mg/mL DMSO 40 mg/mL |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] No authors listed. Med Lett Drugs Ther. Drugs for allergic rhinitis and allergic conjunctivitis
[2] Mawra Jha, et al. Epinastine
[4] No authors listed. Epinastine
[5] Frederick W Fraunfelder. Epinastine hydrochloride for atopic disease
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