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Epimedokoreanin B is a natural flavonoid, which inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B has anticancer, anti-inflammatory and antibacterial activity.
Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation. Epimedokoreanin B (3.13-25 μM; 48 hours) shows significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299. Epimedokoreanin B inhibits M2 polarization in human monocyte-derived macrophages (HMDMs). Epimedokoreanin B suppresses STAT3 activation in HMDMs.
In vivo, Epimedokoreanin B (20 mg/kg; p.o.; thrice a week; for 17 days) inhibits tumor growth in an LM8 tumor-bearing murine model.
| Molecular Weight | 422.47 |
| Formula | C25H26O6 |
| CAS Number | 161068-53-7 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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