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Epimedokoreanin B

Cat. No. M25408
Epimedokoreanin B Structure
Size Price Availability Quantity
5mg USD 1275  USD1275 In stock
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Biological Activity

Epimedokoreanin B is a natural flavonoid, which inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B has anticancer, anti-inflammatory and antibacterial activity.

Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation. Epimedokoreanin B (3.13-25 μM; 48 hours) shows significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299. Epimedokoreanin B inhibits M2 polarization in human monocyte-derived macrophages (HMDMs). Epimedokoreanin B suppresses STAT3 activation in HMDMs.

In vivo, Epimedokoreanin B (20 mg/kg; p.o.; thrice a week; for 17 days) inhibits tumor growth in an LM8 tumor-bearing murine model.

Chemical Information
Molecular Weight 422.47
Formula C25H26O6
CAS Number 161068-53-7
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hao Zheng, et al. Chem Biol Interact. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated paraptosis accompanied by autophagosome accumulation

[2] Cheng Pan, et al. Front Pharmacol. Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment

[3] Toru Kariu, et al. Biosci Biotechnol Biochem. A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis

[4] T Kariu, et al. J Periodontal Res. Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids

[5] Keisuke Nakashima, et al. J Nat Med. Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products

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