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Endoxifen Z-isomer hydrochloride

Cat. No. M6710

All AbMole products are for research use only, cannot be used for human consumption.

Endoxifen Z-isomer hydrochloride Structure
Synonym:

Endoxifen Z-isomer HCl

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Quality Control & Documentation
Biological Activity

Endoxifen Z-isomer hydrochloride is a estrogen receptor α (ERα) ligand; potent antiestrogen. Metabolite of tamoxifen. Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.

Chemical Information
Molecular Weight 409.95
Formula C25H28ClNO2
CAS Number 1032008-74-4
Solubility (25°C) DMSO ≥ 33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chae YJ, et al. Eur J Pharmacol. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels.

[2] Ali SM, et al. Bioorg Med Chem Lett. Endoxifen is a new potent inhibitor of PKC: a potential therapeutic agent for bipolar disorder.

[3] Ahmad A, et al. Breast Cancer Res Treat. Orally administered endoxifen is a new therapeutic agent for breast cancer.

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Keywords: Endoxifen Z-isomer hydrochloride, Endoxifen Z-isomer HCl supplier, Estrogen Receptor, inhibitors, activators

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