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Emodin 6-O-β-D-glucoside

Cat. No. M18272
Emodin 6-O-β-D-glucoside Structure
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Biological Activity

Emodin 6-O-β-D-glucoside

Chemical Information
Molecular Weight 432.38
Formula C21H20O10
CAS Number 34298-85-6
Form Solid
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aki Yamada, et al. Plant Biotechnol (Tokyo). Isolation and characterization of a novel glucosyltransferase involved in production of emodin-6- O-glucoside and rhaponticin in Rheum palmatum

[2] Wonhwa Lee, et al. Inflammation. Emodin-6-O-β-D--glucoside inhibits high-glucose-induced vascular inflammation

[3] Wonhwa Lee, et al. Arch Pharm Res. Emodin-6-O-β-D-glucoside down-regulates endothelial protein C receptor shedding

[4] Wonhwa Lee, et al. Food Chem Toxicol. Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo

[5] Wei Zhang, et al. Biotechnol Lett. Microbial glycosylation of four free anthraquinones by Absidia coerulea

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