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Emodepside

Cat. No. M20980
Emodepside Structure
Synonym:

QHT06, BAY 44-4400, PF 1022-221

Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 230  USD230 In stock
25mg USD 400  USD400 In stock
50mg USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.

Chemical Information
Molecular Weight 1119.39
Formula C60H90N6O14
CAS Number 155030-63-0
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sudhanva S Kashyap, et al. Int J Parasitol Drugs Drug Resist. Diethylcarbamazine mediated potentiation of emodepside induced paralysis requires TRP-2 in adult Brugia malayi

[2] Jrgen Krcken, et al. PLoS Pathog. Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration

[3] Janneke Wit, et al. Int J Parasitol Drugs Drug Resist. Natural variation in Caenorhabditis elegans responses to the anthelmintic emodepside

[4] Lindy Holden-Dye, et al. Invert Neurosci. Worms take to the slo lane: a perspective on the mode of action of emodepside

[5] R J Martin, et al. Exp Parasitol. Emodepside and SL0-1 potassium channels: a review

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Keywords: Emodepside, QHT06, BAY 44-4400, PF 1022-221 supplier, Anti-infection, inhibitors, activators


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