Free shipping on all orders over $ 500

ELQ-300

Cat. No. M10502
ELQ-300 Structure
Synonym:

Endochin-like quinolone-300

Size Price Availability Quantity
5mg USD 340  USD340 In stock
10mg USD 530  USD530 In stock
25mg USD 950  USD950 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

ELQ-300 is a bioavailable antimalarial agent, it is also a potent and orally inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1). ELQ-300 showed significant inhibitory activity on the main parasites responsible for bovine babesiosis and equine piroplasmosis at doses that are tolerable to host cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 475.84
Formula C24H17ClF3NO4
CAS Number 1354745-52-0
Purity >98.5%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

[1] Marta G Silva, et al. Parasit Vectors . Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi

[2] Allison M Stickles, et al. Antimicrob Agents Chemother . Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria

[3] Allison M Stickles, et al. Antimicrob Agents Chemother . Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum

Related Anti-infection Products
PF-07321332

PF-07321332, also known as Paxlovid, is an orally bioavailable 3C-like protease (3CLPRO) inhibitor with an ki of 3.11 nM. PF-07321332 binds directly to the catalytic cysteine (Cys145) residue of the enzyme.

Indolicidin

Indolicidin is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils.

Tenuazonic acid

Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate.

MK-3118

MK-3118 is a novel glucan synthase inhibitor with activity against many echinocandin-resistant strains of Candida due to differential avidity for the target site compared to echinocandins.

Oteseconazole

Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd <39 nM).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ELQ-300, Endochin-like quinolone-300 supplier, Anti-infection, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.