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Elotuzumab

Cat. No. M22514
Elotuzumab Structure
Synonym:

BMS 901608; PDL 063; HuLuc 63

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Quality Control & Documentation
Biological Activity

Elotuzumab is a First-in-Class monoclonal antibody directed against the SLAMF7 receptor, it specifically binds to signaling lymphocyte activating molecule family member 7 (SLAMF7) and activates the body's immune response to attack and kill multiple myeloma cells. Elotuzumab exerts its anti-myeloma effects mainly through ADCC and activation of NK cells. Elotuzumab results in improved response and outcome when combined with other antimyeloma agents. Elotuzumab has no significant antimyeloma activity when given as a single agent with relapsed or refractory multiple myeloma (RRMM).

Chemical Information
CAS Number 915296-00-3
Solubility (25°C) PBS
Storage Store at -80°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Aust Prescr. Elotuzumab for multiple myeloma

[2] No authors listed. Elotuzumab

[3] Meletios A Dimopoulos, et al. N Engl J Med. Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma

[4] No authors listed. Elotuzumab

[5] Sagar Lonial, et al. N Engl J Med. Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma

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Keywords: Elotuzumab, BMS 901608; PDL 063; HuLuc 63 supplier, inhibitors, activators

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