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Molnupiravir (EIDD-2801)

Cat. No. M9605
Molnupiravir (EIDD-2801) Structure
Synonym:

MK-4482; pro-EIDD-1931; CAS#2492423-29-5

Size Price Availability Quantity
10mg USD 68  USD68 In stock
25mg USD 86  USD86 In stock
50mg USD 155  USD155 In stock
100mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Molnupiravir (EIDD-2801) is an orally bioavailable form of a highly potent ribonucleoside analog that inhibits the replication of multiple RNA viruses including SARS-CoV-2, the causative agent of COVID-19. EIDD-2801 (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever. Molnupiravir (EIDD-2801) is efficiently hydrolyzed in vivo after absorption, resulting in detection of only free NHC in plasma. EIDD-2801 robustly reduces MERS-CoV infectious titers, viral RNA, and pathogenesis under both prophylactic and early therapeutic conditions.

Chemical Information
Molecular Weight 329.31
Formula C13H19N3O7
CAS Number 2349386-89-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Timothy P Sheahan, et al. Sci Transl Med. An Orally Bioavailable Broad-Spectrum Antiviral Inhibits SARS-CoV-2 in Human Airway Epithelial Cell Cultures and Multiple Coronaviruses in Mice

[2] Mart Toots, et al. Sci Transl Med. Characterization of Orally Efficacious Influenza Drug With High Resistance Barrier in Ferrets and Human Airway Epithelia

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Keywords: Molnupiravir (EIDD-2801), MK-4482; pro-EIDD-1931; CAS#2492423-29-5 supplier, Anti-infection, inhibitors, activators


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