Edaravone is a radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Edaravone is used for treatment of patients with acute brain infarction. Edaravone protects against MPTP-induced neurotoxicity.
| Molecular Weight | 174.2 |
| Formula | C10H10N2O |
| CAS Number | 89-25-8 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Hiide Yoshino. Edaravone for the treatment of amyotrophic lateral sclerosis
[4] Manoj Kumar Jaiswal. Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs
[5] R Bhandari, et al. Edaravone: a new hope for deadly amyotrophic lateral sclerosis
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