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Echistatin TFA

Cat. No. M10636
Echistatin TFA Structure
Size Price Availability Quantity
1mg USD 1000  USD1000 In stock
5mg USD 2500  USD2500 In stock
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

Echistatin TFA is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1. Echistatin TFA is the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 5531.02
Formula C219H342F3N71O76S9
CAS Number 154303-05-6 (free base)
Purity >95%
Solubility Water 45 mg/mL (May need ultrasonic)
Storage -20°C, dry, sealed
References

[1] I Wierzbicka-Patynowski, et al. J Biol Chem . Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins

[2] C C Kumar, et al. J Pharmacol Exp Ther . Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor

[3] J Musial, et al. Circulation . Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms

[4] M Sato, et al. J Cell Biol . Echistatin is a potent inhibitor of bone resorption in culture

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