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Echinocandin B

Cat. No. M25430
Echinocandin B Structure
Synonym:

A-30912A; NSC 287461

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Quality Control & Documentation
Biological Activity

Echinocandin B is a cyclic hexapeptide echinocandin antibiotic isolated from Aspergillus nidulans var. echinulatus with specific anti-yeast activity. It inhibits beta-1,3-glucan synthesis and thus attacks the cell wall of fungi.

Chemical Information
Molecular Weight 1060.24
Formula C52H81N7O16
CAS Number 54651-05-7
Solubility (25°C) Soluble in DMSO
Soluble in DMF
Soluble in Ethanol
Soluble in Methanol
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shu-Ping Zou, et al. Int J Biol Macromol. Functional expression of an echinocandin B deacylase from Actinoplanes utahensis in Escherichia coli

[2] Zhong-Ce Hu, et al. Prep Biochem Biotechnol. Mutagenesis of echinocandin B overproducing Aspergillus nidulans capable of using starch as main carbon source

[3] M C Shivakumar, et al. 3 Biotech. Deacylation of Echinocandin B by Streptomyces species: a novel method for the production of Echinocandin B nucleus

[4] Johanna Mattay, et al. Appl Environ Microbiol. Cryptic Production of trans-3-Hydroxyproline in Echinocandin B Biosynthesis

[5] Wolfgang Hüttel, et al. BMC Genomics. Echinocandin B biosynthesis: a biosynthetic cluster from Aspergillus nidulans NRRL 8112 and reassembly of the subclusters Ecd and Hty from Aspergillus pachycristatus NRRL 11440 reveals a single coherent gene cluster

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Keywords: Echinocandin B, A-30912A; NSC 287461 supplier, Antibiotic, inhibitors, activators


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