Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME).
| Molecular Weight | 408.58 |
| Formula | C25H36N4O |
| CAS Number | 1128165-88-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Emily Wl Sun, et al. Mol Cell Endocrinol. Dynamin regulates L cell secretion in human gut
| Related Dynamin Products |
|---|
| DynaMin inhibitory peptide, myristoylated
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. |
| Dynamin inhibitory peptide
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. |
| Bis-T-23
Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. |
| DRP1i27 dihydrochloride
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). |
| Trimethyloctadecylammonium bromide
Trimethyloctadecylammonium bromide is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
