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Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection.
In vivo, Dusquetide (SGX942) (25 mg/kg; i.v.; days 0, 4, 7, 10, and 14) shows no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation.
| Molecular Weight | 553.7 |
| Formula | C25H47N9O5 |
| CAS Number | 931395-42-5 |
| Solubility (25°C) | Water 50 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[3] Yi Zhang, et al. Structure. Dusquetide modulates innate immune response through binding to p62
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