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DS18561882

Cat. No. M14691

All AbMole products are for research use only, cannot be used for human consumption.

DS18561882 Structure
Size Price Availability Quantity
1mg USD 120  USD120 In stock
5mg USD 290  USD290 In stock
10mg USD 455  USD455 In stock
25mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile.

Chemical Information
Molecular Weight 608.63
Formula C28H31F3N4O6S
CAS Number 2227149-22-4
Solubility (25°C) DMSO 90 mg/mL
Storage 2-8°C, sealed
References

[1] Ru Zhao, et al. PPFIA4 promotes castration-resistant prostate cancer by enhancing mitochondrial metabolism through MTHFD2

[2] Jin Lee, et al. A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer

[3] Junya Kawai, et al. Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity

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Keywords: DS18561882 supplier, inhibitors, activators

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