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Doxazosin

Cat. No. M20538
Doxazosin Structure
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Biological Activity

Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.

Chemical Information
Molecular Weight 451.48
Formula C23H25N5O5
CAS Number 74191-85-8
Solubility (25°C) DMSO 31 mg/mL
Water 1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ai-Yuan Xiu, et al. Drug Des Devel Ther. Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway

[2] Andrzej Wykretowicz, et al. Expert Opin Pharmacother. Doxazosin in the current treatment of hypertension

[3] David R Goldsmith, et al. Drugs. Doxazosin gastrointestinal therapeutic system: a review of its use in benign prostatic hyperplasia

[4] John D McConnell, et al. N Engl J Med. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia

[5] Domenic A Sica. Congest Heart Fail. Doxazosin and congestive heart failure

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