All AbMole products are for research use only, cannot be used for human consumption.
DOTMA, as a tetra-methylated DOTA analogue, is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA is applied to DNA delivery. Studies have found that single-compartment liposomes prepared by DOTMA can encapsulate DNA and RNA fragments at a high level, with an encapsulation rate of 100%, and can be well taken up by cells to express target genes. The transfection efficiency at the cellular level is 10 times higher than that of DOTAP. The prescription is also simpler, and there is no need to add helper lipids such as DOPE.
| Molecular Weight | 670.57 |
| Formula | C42H84ClNO2 |
| CAS Number | 104872-42-6 |
| Solubility (25°C) | DMSO 10 mg/mL (ultrasonic and warming and heat to 50°C) |
| Storage | -20°C, protect from light, dry, sealed |
[3] Yu Zhang, et al. J Control Release. Progress in microRNA delivery
[5] R W Malone, et al. Proc Natl Acad Sci U S A. Cationic liposome-mediated RNA transfection
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HBpep(RPY)-SP acetate is a variant of the polypeptide HBpep-SP. HBpep(RPY)-SP acetate interacts with lipid bilayers and has demonstrated exceptional transfection efficiency in challenging-to-transfect cells, such as primary and immune cells. HBpep(RPY)-SP acetate is useful for research in protein, gene, and immune cell therapies. |
| Chitosan (≥95% deacetylated, MW 50000-60000)
Chitosan (≥95% deacetylated, MW 50000-60000) is a polycationic linear polysaccharide derived from chitin .Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and antioxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection. |
| DOTAP methylsulfate
DOTAP methylsulfate is a cationic derivative of trimethylammonium attached to two 18-carbon fatty acid tails, each with a single alkene group. 18:1 TAP is a cationic liposome-forming compound useful for the transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells. |
| Chitosan (MW 150000)
Chitosan (MW 150000) is a polycationic linear polysaccharide derived from chitin with a molecular weight of 150000.Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and anti-oxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection. |
| Chitosan (MW 30000)
Chitosan (MW 30000) is a polycationic linear polysaccharide derived from chitin with a molecular weight of 30,000.Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and antioxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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