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Doripenem

Cat. No. M20929
Doripenem Structure
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Biological Activity

Doripenem is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens.

Chemical Information
Molecular Weight 420.50
Formula C15H24N4O6S2
CAS Number 148016-81-3
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chienhsiu Huang, et al. J Clin Med. Doripenem in the Treatment of Patients with Nosocomial Pneumonia: A Meta-Analysis

[2] No authors listed. Doripenem

[3] No authors listed. Doripenem

[4] David L Paterson, et al. Clin Infect Dis. Doripenem

[5] David Leif Anderson. Drugs Today (Barc). Doripenem

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