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Cat. No. M19957
Doramectin Structure

Cyclohexylavermectin B1; Dectomax

Size Price Availability Quantity
10mg USD 50  USD50 In stock
50mg USD 70  USD70 In stock
100mg USD 95  USD95 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Doramectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. It is used for the treatment and control of internal parasitosis, ticks and mange.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 899.11
Formula C50H74O14
CAS Number 117704-25-3
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C

[1] Christopher Pardo, et al. J Acad Consult Liaison Psychiatry. Bugging Out: Human Doramectin Misuse in a Case of Delusional Parasitosis

[2] Mrio Henrique Conde, et al. Vet Parasitol. First report of Dermatobia hominis resistant to doramectin in cattle

[3] M Larroza, et al. Exp Parasitol. Doramectin efficacy against Psoroptes ovis in sheep: Evaluation of pharmacological strategies

[4] Gordon Lye, et al. J Vet Pharmacol Ther. Pharmacokinetics of subcutaneously administered doramectin in alpacas

[5] Alberto M Cordero, et al. Vet Dermatol. Doramectin in the treatment of generalized demodicosis

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Keywords: Doramectin, Cyclohexylavermectin B1; Dectomax supplier, inhibitors

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