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DMH2

Cat. No. M8568

All AbMole products are for research use only, cannot be used for human consumption.

DMH2 Structure

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Biological Activity

DMH2 is a potent antagonist of the BMP receptor activin receptor-like kinase 3 (ALK3, BMPR-IA) that enhance liver regeneration. DMH2 potently inhibits BMP signaling and induced the greatest reduction of cell growth and expression of Id family members in H1299 non-small cell lung carcinoma cells.

Chemical Information
Molecular Weight 451.52
Formula C27H25N5O2
CAS Number 1206711-14-9
Solubility (25°C) DMSO: 1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ga I Ban, et al. Antagonism of BMP signaling is insufficient to induce fibrous differentiation in primary sclerotome

[2] Jenna H Newman, et al. Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer

[3] Daisuke Tsugawa, et al. Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration

[4] Elaine Langenfeld, et al. Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin

[5] Elaine Langenfeld, et al. Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines

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Keywords: DMH2 supplier, inhibitors, activators

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