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DMeOB

Cat. No. M6682

All AbMole products are for research use only, cannot be used for human consumption.

DMeOB Structure

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Biological Activity

DMeOB is a negative allosteric modulator of the metabotropic glutamate receptor mGlu5; displays reversible non-competitive inhibition of mGlu5-mediated responses (IC50 = 3 μM).

Chemical Information
Molecular Weight 268.31
Formula C16H16N2O2
CAS Number 40252-74-2
Solubility (25°C) DMSO 26.83 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Garcia, et al. J Biol Chem. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway.

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