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Dithianon

Cat. No. M29934
Dithianon Structure
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Quality Control & Documentation
Biological Activity

Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others.

Chemical Information
Molecular Weight 296.32
Formula C14H4N2O2S2
CAS Number 3347-22-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuri Lee, et al. Ecotoxicol Environ Saf. Dithianon exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans

[2] European Food Safety Authority (EFSA), et al. EFSA J. Updated peer review of the pesticide risk assessment for the active substance dithianon in light of confirmatory data submitted

[3] Xiaoyu Jiao, et al. Chemosphere. Enhanced photodegradation of applied dithianon fungicides on plant leaves by dissolved substances in atmosphere under simulated sunlight

[4] Fernando J Scariot, et al. Pestic Biochem Physiol. Necrotic cell death induced by dithianon on Saccharomyces cerevisiae

[5] Alice Passoni, et al. Eur J Mass Spectrom (Chichester). Automated online solid-phase extraction-liquid chromatography mass spectrometric analysis of dithianon in water

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