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Distamycin A

Cat. No. M22494
Distamycin A Structure

Stallimycin; NSC-82150

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Biological Activity

Distamycin A (Stallimycin, NSC-82150), an oligopeptide antibiotic, is a minor groove binder which binds to B-form DNA, preferentially at A/T rich sites.Distamycin A can change Enediyne-induced DNA cleavage sites and enhances apoptosis.

Chemical Information
Molecular Weight 481.51
Formula C22H27N9O4
CAS Number 636-47-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Pier Giovanni Baraldi, et al. Bioorg Med Chem. Hybrid molecules between distamycin A and active moieties of antitumor agents

[2] Pier Giovanni Baraldi, et al. Curr Top Med Chem. Distamycin A as stem of DNA minor groove alkylating agents

[3] P Cozzi, et al. Curr Pharm Des. Cytotoxics derived from distamycin A and congeners

[4] M Durand, et al. Biochemistry. Distamycin A complexation with a nucleic acid triple helix

[5] J C Stockert, et al. Histochemistry. DNA-induced distamycin A fluorescence

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Keywords: Distamycin A, Stallimycin; NSC-82150 supplier, Antibiotic, inhibitors, activators

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