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Dihydrorobinetin

Cat. No. M16690
Dihydrorobinetin Structure
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Biological Activity

Dihydrorobinetin

Chemical Information
CAS Number 4382-33-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Miriam Sanz, et al. Anal Chim Acta. Polyphenols in red wine aged in acacia (Robinia pseudoacacia) and oak (Quercus petraea) wood barrels

[2] Miriam Sanz, et al. J Agric Food Chem. Effect of toasting intensity at cooperage on phenolic compounds in acacia (Robinia pseudoacacia) heartwood

[3] Ana B Cerezo, et al. J Agric Food Chem. (+)-Dihydrorobinetin: a marker of vinegar aging in acacia (Robinia pseudoacacia) wood

[4] De-Yu Xie, et al. Plant Physiol. Molecular and biochemical analysis of two cDNA clones encoding dihydroflavonol-4-reductase from Medicago truncatula

[5] D G ROUX, et al. Biochem J. Condensed tannins. 14. Formation of (-)-3', 4', 5', 7-tetrahydroxyflavanone and (plus)-3', 4', 5', 7-tetrahydroxyflavan-4-ol by interconversion from (plus)-dihydrorobinetin, and synthesis of their racemates

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