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Quercetin 3-O-sophoroside

Cat. No. M16617
Quercetin 3-O-sophoroside Structure
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Biological Activity

Quercetin 3-O-sophoroside

Chemical Information
CAS Number 18609-17-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Congming Zou, et al. J Nanobiotechnology. Comparative physiological and metabolomic analyses reveal that Fe 3 O 4 and ZnO nanoparticles alleviate Cd toxicity in tobacco

[2] Teresa M Seifried, et al. Anal Bioanal Chem. Fluorescence signal of proteins in birch pollen distorted within its native matrix: Identification of the fluorescence suppressor quercetin-3-O-sophoroside

[3] Suliman Khan, et al. Arab J Chem. Exploring the interaction of quercetin-3-O-sophoroside with SARS-CoV-2 main proteins by theoretical studies: A probable prelude to control some variants of coronavirus including Delta

[4] Yanling Wang, et al. Food Chem. A comparison of the absorption and metabolism of the major quercetin in brassica, quercetin-3-O-sophoroside, to that of quercetin aglycone, in rats

[5] Hongjuan Li, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Purification of quercetin-3-O-sophoroside and isoquercitrin from Poacynum hendersonii leaves using macroporous resins followed by Sephadex LH-20 column chromatography

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